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This website provides data used in the paper “Construction of Gene Clusters Resembling Genetic Causal Mechanisms for Common Complex Disease with an Application to Young-Onset Hypertension” submitted to BMC Genomics.

l  Figure Related Files (MATLAB® files for generating the following figures are provided):

1.          Figures 3 and 4: Figures_3_and_4.zip (4.0 MB)

2.          Figure 5: Figure_5.zip (5.2 MB)

l  Supplementary data files (supplementary data mentioned in the paper):

1.          Additional file 1:  Additional file 1.pdf

2.          Sample IDs used in the 5 datasets:  Additional file 2.xls

3.          Detailed SNP rs numbers and the associated gene symbols in each of the gene clusters (at the cluster selection stage):  Additional file 3.csv

4.          Detailed SNP rs numbers and the associated gene symbols in each of the gene clusters (at the component pruning stage):  Additional file 4.xls

5.          The selected gene symbols in the 14 gene clusters:  Additional file 5.csv

l  Find necessary genes using gene expression data (Section 2.5. Validation using gene expression data):

1.          Gene Expression Data: merged_subject_expression_data.zip (20.4MB)

2.          Identification of influential genes using gene expression data: identify_influential_genes_via_expression_data.zip (36.1MB)

l  Compute disease SNP pairs (C++ codes with multi-computer multi-thread capability, using for example “g++ -O3 -o ~/test.out ~/disease_SNPpair_2datasets.cpp -l pthread” for compiling in Linux clusters): disease_SNPpair_2datasets.zip

 

 

Please contact Dr. Ke-Shiuan Lynn if you have any questions about the data.